Platform

Microfluidic high-throughput screening platform

A genotype construction platform based on high-throughput flow imaging driven by data has the characteristics of high-throughput, automation, and high sensitivity. By utilizing CRISPR high-throughput genotype construction and droplet microfluidics, ultra high-throughput characterization testing techniques, the relationship between phenotype genes, metabolism, and correlation of HMOs producing strains is deeply explored from the whole genome, such as analyzing the phenotype, genes, metabolism, etc. of HMOs producing strains, and then screening for strains with better expression performance and more stability, achieving efficient strain construction.

advantage

Compatible with microfluidic chips for flow detection and analysis and static co cultured microporous chips, it can achieve high-throughput flow imaging and static scanning, bright field+multi-channel fluorescence, coaxial near coherent light instantaneous focusing, and support single-cell PCR experiments.

Bioinformatics+AI technology platform

The combination of bioinformatics and AI technology plays a synergistic role in enzyme and proteomic research, providing powerful tools and methods for us to gain a deeper understanding of enzyme functions and properties, as well as protein spatial structure simulation. The breakthrough of generative AI technology enables the comprehensive release of the value of biological big data. The complete data loop constructed by "generation feedback optimization" can break through the limits of human computing and bring biological computing into the AI era.

advantage

Empowering upstream optimization through AI algorithms has comprehensive advantages such as reducing by-products, lowering impurities, reducing separation and purification pressure in backend production, and saving raw material costs.

Synthetic Biology Research Platform

By using gene editing technology to optimize chassis cells and construct standardized component libraries, the assembly and expression of exogenous genes can be quickly and efficiently carried out, greatly improving production efficiency.

advantage

By using gene editing technology to optimize chassis cells and construct standardized component libraries, the assembly and expression of exogenous genes can be quickly and efficiently carried out, greatly improving production efficiency.

Fermentation and testing platform

Composed of a fermentation laboratory and a testing laboratory, equipped with fermentation tanks of different volumes ranging from 5L-50L-100L-1000L, the fermentation process is scaled up from 0-1-10, laying the foundation for industrial production. The testing laboratory is equipped with various precision testing instruments, develops multiple testing methods, and completes the detection and separation of target product concentration, impurities, and isomer components, achieving overall optimization of bacterial metabolic pathways, high-density fermentation, high-purity separation and purification, and product quality control.

advantage

Through high-density fermentation and high-purity purification, the target products of human milk oligosaccharides tetrasaccharides and neotetrasaccharides were obtained with a purity of over 92%, which is more than 20% higher than the purity produced by well-known foreign enterprises. The 100L-1000L fermentation tank can meet the sample mass production of some other high value-added biological products, providing conditions for the industrialization of incubating other biological products.